We were founded on the principle that long-lived species possess unique longevity pathways. To this end, our work has led to the DNA sequencing of the world’s oldest known land animal, a giant tortoise named Jonathan, who is estimated to be at least 192 years old. By studying his DNA and epigenome, we have discovered novel mechanisms that show promise for the application to human longevity.

We also believe that there is a critical need for human clinical trials involving generic drugs that have demonstrated longevity-enhancing effects in model organisms. Traditional drug companies don’t have the financial incentive to conduct human trials with these off-patent drugs. As a non-profit organization, Kallel is not constrained by these financial limitations.

Initial goals:

1. Accelerate human clinical trials for generic drugs demonstrating promise in model systems.

2. Discover new methods to advance mitochondrial rejuvenation.

3. Identify additional novel longevity mechanisms from long-lived species.